Umie Aida Izinkan Suami Menikah Lagi, Ini Sebabnya!

Kenyataan mengejutkan datang dari pelakon dan penyanyi, Datin Umie Aida, yang mengungkapkan jika suaminya diperbolehkan untuk menambah isteri lagi atau dimadu. Pathophysiology Mesothelioma Fundamental The mesothelium comprises of a solitary layer of leveled to cuboidal cells shaping the epithelial covering of the serous depressions of the body including the peritoneal, pericardial and pleural holes. Statement of asbestos filaments in the parenchyma of the lung may bring about the entrance of the instinctive pleura from where the fiber would then be able to be conveyed to the pleural surface, in this manner prompting the advancement of harmful mesothelial plaques. The procedures prompting the improvement of peritoneal mesothelioma stay uncertain, despite the fact that it has been recommended that asbestos strands from the lung are transported to the belly and related organs by means of the lymphatic framework. Furthermore, asbestos strands might be kept in the gut after ingestion of sputum tainted with asbestos fibers.[citation needed] Pleural tainting with asbestos or other mineral strands has been appeared to cause growth. Long thin asbestos strands (blue asbestos, amphibole filaments) are more powerful cancer-causing agents than "padded filaments" (chrysotile or white asbestos fibers).[26] However, there is presently prove that littler particles might be more risky than the bigger strands. They stay suspended noticeable all around where they can be breathed in, and may enter all the more effectively and more profound into the lungs. "We most likely will discover significantly more about the wellbeing parts of asbestos from [the World Trade Center attack], lamentably," said Dr. Alan Fein, head of aspiratory and basic care prescription at North Shore-Long Island Jewish Health System.[47] Mesothelioma advancement in rats has been shown following intra-pleural immunization of phosphorylated chrysotile strands. It has been recommended that in people, transport of strands to the pleura is basic to the pathogenesis of mesothelioma. This is bolstered by the watched enrollment of noteworthy quantities of macrophages and different cells of the insusceptible framework to restricted injuries of aggregated asbestos strands in the pleural and peritoneal holes of rats. These sores kept on drawing in and aggregate macrophages as the sickness advanced, and cell changes inside the sore finished in a morphologically threatening tumor.[citation needed] Exploratory confirmation proposes that asbestos goes about as a total cancer-causing agent with the improvement of mesothelioma happening in consecutive phases of inception and advancement. The atomic systems fundamental the threatening change of typical mesothelial cells by asbestos strands stay vague in spite of the exhibit of its oncogenic capacities (see straightaway yet one passage). Be that as it may, finish in vitro change of typical human mesothelial cells to a threatening phenotype following presentation to asbestos filaments has not yet been accomplished. As a rule, asbestos strands are thought to act through direct physical communications with the cells of the mesothelium in conjunction with backhanded impacts following collaboration with provocative cells, for example, macrophages.[citation needed] Intracellular Examination of the cooperations between asbestos filaments and DNA has demonstrated that phagocytosed strands can reach chromosomes, frequently clinging to the chromatinfibers or getting to be trapped inside the chromosome. This contact between the asbestos fiber and the chromosomes or basic proteins of the shaft mechanical assembly can initiate complex variations from the norm. The most widely recognized variation from the norm is monosomy of chromosome 22. Other regular variations from the norm incorporate basic revision of 1p, 3p, 9p and 6q chromosome arms.[citation needed] Regular quality variations from the norm in mesothelioma cell lines incorporate cancellation of the tumor silencer genes:[citation needed] • Neurofibromatosis write 2 at 22q12 • P16INK4A[48] • P14ARF Asbestos has additionally been appeared to intercede the section of remote DNA into target cells. Consolidation of this remote DNA may prompt transformations and oncogenesis by a few conceivable components: • Inactivation of tumor silencer qualities • Activation of oncogenes • Activation of proto-oncogenes because of consolidation of outside DNA containing a promoter area • Activation of DNA repair catalysts, which might be inclined to blunder • Activation of telomerase • Prevention of apoptosis A few qualities are generally changed in mesothelioma, and might be prognostic elements. These incorporate epidermal development factor receptor (EGFR) and C-Met, receptor tyrosine kinaseswhich are overexpressed in numerous mesotheliomas. Some affiliation has been found with EGFR and epithelioid histology however no unmistakable affiliation has been found between EGFR overexpression and general survival. Articulation of AXL receptor tyrosine kinase is a negative prognostic factor. Articulation of PDGFRB is a positive prognostic factor.[49] all in all, mesothelioma is portrayed by loss of capacity in tumor silencer qualities, as opposed to by an overexpression or pick up of capacity in oncogenes.[50] As an earth activated harm, mesothelioma tumors have been observed to be polyclonal in cause, by playing out a X-inactivation construct measure in light of epitheloid and biphasic tumors acquired from female patients.[51] These outcomes recommend that an ecological factor, doubtlessly asbestos introduction, may harm and change a gathering of cells in the tissue, bringing about a populace of tumor cells that are, though just somewhat, hereditarily different.[citation needed] Resistant framework Asbestos strands have been appeared to change the capacity and secretory properties of macrophages, at last making conditions which support the advancement of mesothelioma. Following asbestos phagocytosis, macrophages create expanded measures of hydroxyl radicals, which are typical side-effects of cell anaerobic digestion. Notwithstanding, these free radicals are likewise known clastogenic (chromosome-breaking) and layer dynamic operators thought to advance asbestos cancer-causing nature. These oxidants can take an interest in the oncogenic procedure by straightforwardly and by implication connecting with DNA, changing layer related cell occasions, including oncogene enactment and irritation of cell cancer prevention agent defences.[citation needed] Asbestos additionally may have immunosuppressive properties. For instance, chrysotile strands have been appeared to discourage the in vitro expansion of phytohemagglutinin-empowered fringe blood lymphocytes, stifle common executioner cell lysis and essentially decrease lymphokine-enacted executioner cell suitability and recuperation. Moreover, hereditary changes in asbestos-actuated macrophages may bring about the arrival of strong mesothelial cell mitogens, for example, platelet-inferred development factor (PDGF) and changing development factor-β (TGF-β) which thusly, may incite the incessant incitement and multiplication of mesothelial cells after damage by asbestos filaments

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